The Relationship Between Cystatin-C Levels and The Degree of Anemia in Patients with Stage V Chronic Kidney Disease Undergoing Hemodialysis at RSUD Dr. Mohamad Soewandhie Surabaya

Ulfiah Ulfiah; Rahajoe Imam Santoso; Yahya Haryo Nugroho

doi:10.55606/ijhs.v6i1.6880

Authors

Ulfiah Ulfiah Universitas Ciputra
Rahajoe Imam Santoso Universitas Ciputra
Yahya Haryo Nugroho Universitas Ciputra

DOI:

https://doi.org/10.55606/ijhs.v6i1.6880

Keywords:

Cystatin-C, Chronic Kidney Disease, Cross-Sectional Study, Degree of Anemia, Hemodialysis

Abstract

Chronic kidney disease (CKD) is a progressive and irreversible condition with increasing prevalence and a high risk of complications, including anemia in advanced stages. Renal function is often assessed using serum creatinine, but this biomarker is influenced by factors like muscle mass, race, and diet. This highlights the need for more accurate alternative biomarkers. Cystatin C, a sensitive marker of kidney function, is relatively unaffected by muscle mass or race, making it a recommended parameter for estimating glomerular filtration rate (GFR). Despite its potential, studies examining the relationship between cystatin C levels and anemia in CKD patients are limited. This study aimed to investigate the association between cystatin C levels and the degree of anemia in patients with stage V CKD at RSUD dr. Mohamad Soewandhie Surabaya. The observational, cross-sectional study involved 30 patients undergoing hemodialysis. Anemia severity was classified into mild, moderate, and severe categories. The results showed that most patients had moderate anemia (70%), followed by severe anemia (23.3%) and mild anemia (6.7%). The mean cystatin C level was 2.32 ± 1.09 mg/L. Using the Kruskal–Wallis test, no significant differences in cystatin C levels were found across the anemia severity groups (H = 0.028; p = 0.986). This indicates that cystatin C levels were not significantly associated with the degree of anemia in patients with stage V CKD at the study site. Further research with larger sample sizes is needed to confirm these findings.

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